Sex determination in most organisms involves a simple binary fate choice between male or female development; the outcome of this decision has profound effects on organismal biology, biochemistry and behaviour. In the nematode C. elegans, there is also a binary choice, either male or hermaphrodite. In C. elegans, distinct genetic pathways control somatic and germline sexual cell fate. Both pathways share a common set of globally acting regulatory genes; however, germline-specific regulatory genes also participate in the decision to make male (...) or female gametes. The determination of sexual fate in the germline of the facultative hermaphrodite poses a special problem, because first sperm then oocytes are produced. It has emerged that additional layers of post-transcriptional regulation have been imposed to modulate the activities of the global sex-determining genes, tra-2 and fem-3; the balance between these activities is crucial in controlling sexual cell fate in the hermaphrodite germline. BioEssays 23:596–604, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

This paper interprets and analyzes the debate having taken place in 1995 between E. Gellner and A. Smith concerning the problem of the emergence of nations. This discussion is used as an example to show the basic general features of two approaches in theories of nationalism - the modernist and the ethno symbolic ones. Pointing to the common assumptions shared by Gellner's and Smith's theories of nations, the author interprets ethno-symbolism as a sort of internal self-criticism of the modernist standpoint. (...) This polemic is therefore interpreted not as a debate between "creationist" and "evolutionist" solutions to the problem of the emergence of nations, but rather as a debate between two theoretical paradigms defining different research priorities in studying nations and nationalisms. From this perspective, the author concludes that the ethno symbolic approach to the genealogy of nations has broader heuristic capacities than the modernist paradigm, at least when the emergence of "peripheral nations" and the understanding of the dynamic of their nationalisms are concerned. U radu je interpretiran i analiziran spor koji su vodili E. Gelner i A. Smit 1995. godine o problemu nastanka nacija. Na primenu ove diskusije prikazane su osnovne opste karakteristike dva pristupa u teorijama nacionalizma modernistickog i etnosimbolickog. Ukazujuci na zajednicke pretpostavke Gelnerove i Smitove teorije nacija, autor je etnosimbolizam tumacio kao jednu vrstu unutrasnje samokritike modernistickog stanovista. Na taj nacin, ova polemika nije interpretirana kao spor izmedju "kreacionistickog" i "evolucionistickog" resenja problema nastanka nacija, vec prevashodno kao spor dve teorijske paradigme koje razlicito odredjuju istrazivacke prioritete u tematizaciji nacija i nacionalizama. Sa tog stanovista, autor je zakljucio da etnosimbolicki pristup genealogiji nacija ima vece heuristicke kapacitete od modernisticke paradigme, bar kada je u pitanju problem nastanka "perifernih nacija " i razumevanja dinamike njihovih nacionalizama. (shrink)

In diesem Texte werden die Kriterien zur Differenzierung von historischen, politischen und heroischen Generationen und ihren Hauptarten in USA, BR Deutschland, China, Serbien und Croatien er?rtert. Kriege und Revolutionen werden als zentrale generationsschaffende Ereignisse markiert. Es werden auch die konstruierten wie auch zugeschriebenen Generationsidentit?tsarten dargestellt. Die Generation ist als eine mehr oder wenig klare Gruppe aufgefa?t, die durch Zusammensetzung von biographischem und kollektivem Ged?chtnis entstanden ist. Die Generation als eine Art von Zeitstruktur ist bei der Reduktion und Erkl?rung der Vergangenheit (...) anwendbar. Es ist immer eine offene Frage in welchem Masse die Generationen die realen handelnden Subjekte, oder blo?e symbolische Heimat, dh. eine durchg?ngige Erinnerungsgemeinschaft sind? Es wird auf die Gr?nden der Entstehung der balkanischen heroischen Generationen hingewiesen, auf ihre Natur und Aktualit?t. In Westeuropa ist diese Art von Generation schon lange nicht mehr aktuell. Es wird auch darauf hingewiesen, dass durch die Heroisierung einer Generationserfahrung die Herrschaftsgruppen eigene Werte oktroyieren k?nnen. Razmotreni su kriteriji razlikovanja istorijskih, politickih i herojskih generacija i prikazani njihovi konkretni primeri u SAD, SR Nemackoj, NR Kini Srbiji i Hrvatskoj. Ratovi i revolucije su uoceni kao glavni generacijski formativni dogadjaji, ali su prikazani i oblici konstruisanog i pripisanog generacijskog samoopisa. Generacija je rastumacena kao manje ili vise prepoznatljiva grupa formirana prozimanjem biografskog i kolektivnog pamcenja. Kao jedna od kategorija u mrezi slozenih vremenskih struktura generacija je korisna kod redukovanja i objasnjenja slozenosti proslosti. Otvoreno je pitanje koliko su generacije realni akteri promena, a koliko tek simbolicki vremenski zavicaj, tj. efemerna zajednica secanja? Blize su analizirani uzroci nastanka, priroda i aktuelnost balkanskih herojskih generacija. U Zapadnoj Evropi ova vrsta generacija odavno nije aktuelna. Uoceno je da se heroizacijom iskustva jedne generacije mogu uspesno nametati vrednosti vladajucih grupa. (shrink)

Tato studie se zabývá zobrazováním alchymie v malbách, knižních ilustracích i v architektuře v období raného novověku. Na jednotlivých příkladech obrazů či ilustrací prezentuje různé aspekty alchymistova života i jeho práce. Nezabývá se symbolickou alchymickou ikonografií, ale zaměří se především na zobrazování prostředí a vybavení alchymických dílen i osobností samotných alchymistů. Soustředí se zejména na vyobrazení zařízení alchymických laboratorií, s nimiž se lze setkat jak u renesančních malířů, tak v ilustracích alchymických rukopisů a poměrně ojediněle i v české architektuře. Poskytuje (...) také pohled na vyobrazení vzniklá v souvislosti s literární kritikou alchymie. Alchymisté byli zejména v dílech předních evropských humanistů často záměrně zesměšňováni, kritizováni a označováni za blázny a zloděje. V závěru se zabývá vybranými příklady ze žánrového umění, kde byli rovněž alchymisté zobrazováni často satiricky, ale i s určitou úctou, jako vzdělaní učenci. Výtvarné umění raného novověku nám představuje různé aspekty života alchymistů a je v dnešní době jednou z možností, jak se přiblížit porozumění jejich vědeckým aktivitám. Jak však studie ukazuje, k těmto obrazovým materiálům je třeba přistupovat kriticky. (shrink)

Zkoumání je založeno na reflexi sémantického pojetí vědec- kých teorií Ronalda Giera. Gierova východiska a závěry jsou podrobeny kritice, na jejímž základě autor buduje svou vlastní variantu modelově založeného pojetí teorií. Hlavním cílem příspěvku je konceptualizace vztahu mezi principy a modely s důrazem na to, že tento vztah může zakládat dynamiku teorie, respektive posloupnosti teorií. Souhrnně bude v příspěvku prověřována řada tezí: 1) Základními prvky teorie jsou modely, které slouží jako nosiče principů. 2) Modely hrají rozhodující roli při pojmové výstavbě (...) teorie. 3) Modely artikulací principů odhalují poznatky, které ze samotných principů neplynou. 4) Principy mohou být někdy souhrnně definovány až poté, co existuje odpovídající množina modelů. 5) Nová teorie nastoupí ve chvíli, kdy je cluster nových modelů dostatečně komplexní a když si vědecké společenství ujasní, že tento nový cluster je založen na určité množině nových principů. (shrink)

Aspiracija za jedinstvenim upravljanjem svetom je stara koliko i sam svet. Ona u suštini proizlazi iz naše percepcije sveta kao jednog, bez obzira na sve razlike koje se u njemu takođe vide. U naše vreme ova percepcija je pojačana utiskom o sve većoj međuzavisnosti delova sveta, kao i osećajem da su razlike, ma koliko bile velike, sve manje važne u odnosu na ono što je isto ili bar slično u različitim delovima sveta. Ovaj osećaj jedinstva je još više pojačan percepcijom (...) potrebe, ili nužde, da se o važnim stvarima u svetu odlučuje i upravlja na jedinstven način, bez kolizija koje bi proces odlučivanja učinile neefikasnim ili nemogućim. Ali jedinstvo sveta bi trebalo da u sebi sadrži ideju ravnopravnosti, i neke načelne jednakosti. Međutim, uvidom u način na koji se ovaj proces unifikacije sveta stvarno odvija vidimo mnoge probleme. Neki od njih su za očekivati – problemi reprezentacije i pristanka na svetsku vlast koja bi bila odraz jedinstvene zakonodavne volje čovečanstva. Takva volja možda uopšte ne može da se konstituiše. Umesto nje imamo volju za hegemonijom koju prati ideja nejednakosti i manihejske podele sveta na naš i tuđi deo, kao i razne vrste pokušaja ukidanja onog uslova koji svakom zakonodavstvu daje njegov legitimet – a to je sloboda. Suočavamo se sa idejom da je, kao uslov mira i demokratije (šta god da to znači, ili što će značiti u bližoj i daljoj budućnosti) potrebno uspostaviti krutu nejednakost i rigidnu kontrolu svih različitosti u jednom zamrznutom stanju podele na povlašćene i obezvlašćene, na „dobre“ i „loše“ momke, kao da se svet sastoji od „momaka“. Ključni deo ove sheme je pretpostavka o univerzalnoj samerljivosti svega što život čini vrednim. Ta pretpostavka uniformiše i simplifikuje, smanjuje, svet, negirajući relevanciju i stvarnost razlikama koji sada predstavljaju stvarnost sveta. Zakoni više ne pretpostavljaju postojanje zakonodavne volje. U toj situaciji proizvodnja ogromne količine iluzorne sreće više liči na podmićivanje svetskog lumpenproletarijata, sa rizikom da celokupno čovečanstvo postane totalno ravnodušno prema svakoj posebnosti i svakoj vrlini, sasvim primereno svojoj novoj lumpenproleterskoj prirodi. (shrink)

Petrić, koji na Pletonovu tragu spise poznate pod naslovom Kaldejska proroštva pripisuje Zoroastru, »suvremeniku Abrahamovu, prvom otkrivaču astrologije i magije tj. mudrosti«, objavljuje te spise u »Dodatku« svoje Nove sveopće filozofije 1591. te 1593. godine pod naslovom Zoroaster et eius CCCXX Oracula Chaldaica, eius opera e tenebris eruta et latine reddita . Spisi će 1593. godine kao zasebno izdanje biti objavljeni u Hamburgu pod naslovom Magia philosophica hoc est Zoroaster et eius CCCXX Oracula chaldaica .Zoroastru pripisanu filozofiju Petrić zajedno sa (...) svojom vlastitom i s još tri filozofije, kao jednu »pobožnu filozofiju« podastire papi Grguru XIV. u zamjenu za Aristotelovu »bezbožnu « filozofiju što se »posvuda predaje po školama«.Prema njegovim vlastitim riječima, Petrić ulaže »nemali trud« u prikupljanje 324 stiha Kaldejskih proroštava, raspršenih po djelima različitih autora poglavito novoplatoničke orijentacije, sakupljajući ih u jedan cjelovit spis, koji raspoređuje u nekoliko tematskih cjelina i prevodi na latinski.U tekstu se nastoje sagledati Petrićevi motivi izdavanja Zoroastru pripisanih Oracula chaldaica, što se povezuje prije svega s pitanjem o tome jesu li i, ako jesu, kako su učenja iz Oracula prisutna u njegovoj vlastitoj filozofiji izloženoj u Novoj sveopćoj filozofiji.Svoj načelni stav o tome kako Proroštva funkcioniraju u njegovoj filozofiji iznosi Petrić u šestoj knjizi »Panarchije« Nove sveopće filozofije gdje kaže: »Ali mi filozofiramo pozivajući se na autoritete [pri čemu misli prije svega na Zoroastra] više kao na ures nego kao na temelj. Pozabavimo se stoga dokazima!« Premda, naime, Zoroastra priznaje kao autoritet, Petrić njegove izrijeke ne smatra filozofskim dokazima!Analizom Nove sveopće filozofije pokušava se u tekstu doći do odgovora na pitanje stoji li ova Petrićeva tvrdnja o pozivanju na autoritete kao na ures. Ujedno se nastoji sagledati specifičnost njegove interpretacije Kaldejskih proroštava, napose interpretacije koncepcije počela u njima izložene.Na kraju su značajke Petrićeve recepcije tih spisa rezimirane u jednoj njegovoj izjavi, vezanoj doduše uz pitanje razuma, no koja se može primijeniti i na sva ostala učenja izložena u Oracula chaldaica. Petrić u njoj znakovito kaže: »Međutim ta [sc. Zoroastrova] povijest o razumu ne čini se da se mnogo tiče naše filozofije, niti se pak mnogo razlikuje od nje.«The article attempts to examine Petrić’s motives for publishing Oracula Chaldaica, attributed to Zoroaster, and relate them primarily with the question of whether the teachings from the Oracles are present, and if so, in what way are they present in Petrić’s philosophy laid out in his Nova de universis philosophia.Petrić introduces his basic position on how Oracles function in his philosophy in the sixth book of “Panarchia” in Nova de universis philosophia, where he says: “But we philosophise by appealing to the authorities [by which he primarily means Zoroaster] more in the sense of an ornament than in the sense a foundation. Let us therefore deal with proofs!” Although, in fact, Petrić recognizes Zoroaster as an authority, he does not regard his sayings as philosophical proofs!Through the analysis of Nova de universis philosophia the article tries to answer the question whether the claim of appealing to the authorities merely as an ornament is justified. At the same time, it tries to expound the particularity of his interpretation of Chaldean Oracles, especially the interpretation of the notion of substance found in Oracles.Finally, the features of Petrić’s reception of these writings are summarized in one of his statements, although connected to the issue of reason, but which can be applied to all of the teachings of Oracula Chaldaica. He indicatively states: “However, this [sc. Zoroaster’s] history of reason does not seem to concern our philosophy very much, nor does it greatly differ from it.”. (shrink)

A szabadság dilemmái -- A megrendült öntudat mítoszai -- Irás az éthoszról.

Throughout the long history of Classic Maya hieroglyphs, a logosyllabic writing system used from the late first millennium BCE through the mid-second millennium CE in southern Mesoamerica, the most commonly recorded phonetic value was the syllable u (/ʔu/). With over a dozen different u hieroglyphs, Classic Maya scribes had more options for recording /ʔu/ than any other syllable or logograph. Cognitive approaches to writing systems typically attribute graphemic variation (i.e., alternation between signs with equivalent linguistic value) to semantic differences like (...) animacy or to non-linguistic factors like identity. Distribution of Classic Maya u hieroglyphs, however, suggests that morphosyntactic context influenced which grapheme scribes wrote and when. This case suggests that scribal knowledge of Classic Maya hieroglyphs included ideas about writing's relationship to language. It also highlights the cognitive relevance of morphosyntax for a writing system's users as they differentiate among graphic signs with identical linguistic denotation. (shrink)

A scholarly edition of The Clarendon Edition of the Works of John Locke: Correspondence: Letters 2665-3286 by E. S. de Beer. The edition presents an authoritative text, together with an introduction, commentary notes, and scholarly apparatus.

Open peer commentary on the article “Second-Order Science: Logic, Strategies, Methods” by Stuart A. Umpleby. Upshot: Second-order science requires a specific methodology. It thereby reverses the classical observer-observed relation in favor of the observed - i.e., the first-order observers - if the principle of autopoiesis is acknowledged.

The Casimir force between two neutral metallic plates is often considered conclusive evidence for the reality of electromagnetic zero-point fluctuations in 'empty space' (i.e. in absence of any boundaries). However, it is not well known that the Casimir force can be derived from many different points of view. The purpose of this note is to supply a conceptually oriented introduction to a representative set of these different interpretations. The different accounts suggest that the Casimir effect reveals nothing conclusive about the (...) nature of the vacuum. (shrink)

Talent and Education was first published in 1960. Minnesota Archive Editions uses digital technology to make long-unavailable books once again accessible, and are published unaltered from the original University of Minnesota Press editions.The problem of identification, development, and utilization of talented young people is a matter of prime concern to all who are interested in the welfare of the individual and the future of the nation. This book, constituting a progress report on research related to the problem, will be of (...) particular value to educators, psychologists, social workers, community leaders, and others who are engaged in the effort to make the most of our human resources.The volume contains chapters by a number of contributors drawn from various fields in elementary, secondary, and higher education. The contributors include John E. Anderson, Robert H. Beck, Florence N. Brumbaugh, Walter W. Cook, Willis E. Dugan, Dale B. Harris, Arthur J. Lewis, Catherine Cox Miles, Mary Pilch, Maynard C. Reynolds, Anne Roe, Merrill F. Roff, Paul C. Rosenbloom, Audrey Shechtman, and E. Paul Torrance. Orville L. Freeman, governor of Minnesota, writes an indtroduction.Among the topics discussed are the nature and scientific measurement of talent, the effects of life experiences on the development of talent, the enrichment of school curricula, special grouping and acceleration in the schools, psychological aspects of some of the problems, and Russian methods of dealing with individual differences. The volume is based on papers from an Institute on Exceptional Children held at the University of Minnesota. (shrink)

This book is the most comprehensive, integrated explanatory account yet published of the properties of question formations and their variation across languages. It makes an important contribution to the current debate over whether syntax should be understood derivationally, arguing that thebest model of language is one in which sentences are constructed in a series of operations that precede or follow each other in time. The central problem it addresses is the nature of the difference between (a) languages in which all (...) wh-words move overtly to a clause-initial position (exemplified byBulgarian); (b) languages in which one wh-phrase moves per clause but all others remain in situ (exemplified by English); and (c) languages in which there is no overt movement at all (exemplified by Japanese). Professor Richards focuses on the nature of syntactic movement in order to see what this reveals about the syntactic derivation. He considers the nature of interactions between movement operations and investigates the behaviour of multiple overt wh-movement, scrambling, cliticization, and objectshift. His general conclusions about the relationship between movement and multiple specifiers follow straightforwardly from basic principles of Shortest Move and Shortest Attract. He develops a PF-imposed well-formedness condition on movement chains (essentially, a requirement that a single memberof the chain be unambiguously identified as the copy to be pronounced), which allows for the development of theories of anti-agreement, the that-trace effect, and the conditions on participial agreement in Romance, among other phenomena. He defends the claim that well-formed dependencies can improvethe status of ill-formed dependencies created later in the derivation, illustrating the explanatory power, under certain structural conditions, of his Principle of Minimal Compliance. He uses data on the locality of wh-movement to argue that the Principle of Minimal Compliance is responsible for anumber of the apparent distinctions between overt and covert movement. This book will interest syntacticians at graduate level and above as well as linguistic theorists concerned with the syntax-semantics interface. (shrink)

Vaccines are not the only public health tool, but they are critical in routine and emergency settings. Achieving optimal vaccination rates requires timely access to vaccines. However, we have persistently failed to secure, distribute, and administer vaccines in a timely, effective, and equitable manner despite an enduring rhetoric of global health equity.